Next-Generation Sequencing in Prostate Cancer
نویسندگان
چکیده
منابع مشابه
Strategies and Clinical Applications of Next Generation Sequencing
Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
متن کاملStrategies and Clinical Applications of Next Generation Sequencing
Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
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A wide spectrum of non-protein based biomarkers are under development that promises to revolutionize the care of prostate cancer (CaP) patients. In the context of CaP detection we highlight the potential value of the urine tests PCA3 and Prostarix(TM), especially for their ability to stratify patient risk with previous negative biopsy for occult cancer. The search for such markers is made more ...
متن کاملRetrospective study testing next generation sequencing of selected cancer-associated genes in resected prostate cancer
PURPOSE Prostate cancer (PCa) has a highly heterogeneous outcome. Beyond Gleason Score, Prostate Serum Antigen and tumor stage, nowadays there are no biological prognostic factors to discriminate between indolent and aggressive tumors.The most common known genomic alterations are the TMPRSS-ETS translocation and mutations in the PI3K, MAPK pathways and in p53, RB and c-MYC genes.The aim of this...
متن کاملNext generation sequencing and urologic cancer
Nucleic acid sequencing is a method for identifying the exact nucleotides present in a given DNA or RNA molecule. After completion of the first human genome sequence from the Human Genome Project by f irstgeneration sequencing (also known as Sanger sequencing), the use of nucleic acid sequencing has greatly increased in research and clinical investigations worldwide, with a resultant demand for...
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ژورنال
عنوان ژورنال: The Korean Journal of Urological Oncology
سال: 2020
ISSN: 2234-4977,2233-5633
DOI: 10.22465/kjuo.2020.18.1.18